안녕하세요, KOLIS 회원 여러분.

스탠포드 KOLIS 첫 저널 클럽이 2월 23일 저녁 6시 30분에 있습니다.
장소는 Li Ka Shing Center (LKSC) 208호입니다.

2012년도의 첫 연사분은 Department of Pediatrics에 계시는 박권식 박사님이십니다.

최근에 내신 Nature Medicine 논문 내용을 저자분께 직접 들을 수 있는 좋은 시간일 것 같습니다.
http://www.nature.com/nm/journal/v17/n11/abs/nm.2473.html

저널 클럽 내용은 아래를 참고하여 주시면 감사하겠습니다.

Abstract

For many tumors, little is known of the mechanisms underlying tumor initiation and progression while much of the mechanisms of tumor homeostasis still remains to be determined. The overarching of our research is to understand the mechanisms underlying tumorigenesis using models of human small cell lung cancer (SCLC). SCLC is an aggressive neuroendocrine subtype of lung cancer for which there is no effective treatment. Using a mouse model in which deletion of Rb1 and Trp53 in the lung epithelium of adult mice induces SCLC, we found that the Hedgehog signaling pathway is activated in SCLC cells independently of the lung microenvironment. Constitutive activation of the Hedgehog signaling molecule Smoothened (Smo) promoted the clonogenicity of human SCLC in vitro and the initiation and progression of mouse SCLC in vivo. Reciprocally, deletion of Smo in Rb1 and Trp53-mutant lung epithelial cells strongly suppressed SCLC
initiation and progression in mice. Furthermore, pharmacological blockade of Hedgehog signaling inhibited the growth of mouse and human SCLC, most notably following chemotherapy. These findings show a
crucial cell-intrinsic role for Hedgehog signaling in the development and maintenance of SCLC and identify Hedgehog pathway inhibition as a therapeutic strategy to slow the progression of disease and delay
cancer recurrence in individuals with SCLC. 

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